Jefferson University Hospitals

IVF with Comprehensive Chromosome Screening

Performed only as a component of some in vitro fertilization (IVF) treatments, comprehensive chromosome screening (CCS) is a sampling of cells from the developing embryo for genetic testing. The majority of failed IVF cycles and pregnancy losses are likely to arise from abnormal chromosomes in the developing embryo. Testing these cells for the correct number of chromosomes is a way to confirm that the embryo will have a normal number of chromosomes.

Candidates for CCS may include patients 35 years of age and older or those who have experienced multiple unsuccessful in vitro fertilization cycles or recurrent miscarriages.

To find out if you're a candidate of CCS, seek an evaluation with one of our fertility specialists at Reproductive Medicine Associates (RMA) at Jefferson in Philadelphia.

Genetic screening of the embryos can improve your chance of having a healthy baby and reduce the risk of miscarriage after IVF treatment.

What Does Comprehensive Chromosome Screening Involve?

Without injuring the cells that will become the baby, several placental cells are removed from a day-five embryo (called a blastocyst) and are tested. Embryo survival after this method is extremely high.

After comprehensive chromosome screening, only embryos that have the correct number of chromosomes are selected for transfer. The transfer may be in the same cycle (fresh transfer) or embryos may be frozen for future use in a frozen cycle.

Because CCS is more predictive of the health of the embryo than the appearance of the embryo under the microscope, the test may also enhance pregnancy rates in younger women trying to determine which single embryo to transfer into the uterus.

Why Choose RMA at Jefferson for IVF with Comprehensive Chromosome Screening?

RMA at Jefferson doctors and embryologists developed the technology for comprehensive chromosome screening and are experts in performing this procedure.

Our reproductive endocrinologists are specially trained in infertility therapy and are board certified in obstetrics and gynecology and reproductive endocrinology. Our doctors work with expert embryologists in an Embryology Laboratory that is accredited by The Joint Commission.

Our physicians and embryologists offer the most advanced treatment options and consistently achieve pregnancy rates that are above the national average.

See Our Exceptional Pregnancy Success Rates with IVF >

Schedule an Appointment with a Fertility Expert

To schedule an appointment with one of our fertility specialists, please call 215-922-1556.

Flexible financing options, a refund guarantee program, military and first-responder discounts, and financial aid programs each aim to make our world-class care as widely available as possible. To reach out to a financial counselor, please e-mail