Jefferson University Hospitals

Prostate Cancer Genetic Testing

Our experts at Jefferson's Clinical Cancer Genetics Service will work with you to identify if you are predisposed to prostate cancer.

For some patients, their prostate cancer is hereditary. In fact, about five to 10 percent of all prostate cancers are hereditary. This means, an increased risk for prostate cancer runs in the family or an individual has a high chance of developing prostate cancer during his life, particularly at a young age.

Genetic Testing Criteria for Hereditary Prostate Cancer

You may meet criteria for hereditary prostate cancer if any of the following are observed for you and/or your family:

  • Three or more first degree relatives (father, brother, son) with prostate cancer
  • Three generations in a row (grandfather, father, son) with prostate cancer on either the maternal or paternal side
  • At least two relatives affected at or before the age of 55
  • Diagnosed with cancer before the age of 60
  • Strong family history of other cancers such as breast, colon, prostate, upper tract urothelial, uterine or ovarian cancer

Prostate cancer has also been linked to other cancers such as breast and colon cancers. Inherited mutations of the BRCA1 or BRCA2 genes which increase the risk of breast and ovarian cancers may also increase prostate cancer risk in some men.

Individuals with Lynch syndrome (also known as hereditary non-polyposis colorectal cancer, or HNPCC), a condition caused by inherited gene changes, have an increased risk for a number of cancers such as colon cancer, uterine cancer and ovarian cancer. There is increasing evidence that some prostate cancers may be associated with Lynch syndrome.

Make an Appointment

Please call Laura Gross, BA (Program Manager), at 215-503-5285, to schedule an appointment or for more information about hereditary prostate cancer.