Jefferson University Hospitals

Vickie & Jack Farber Institute for Neuroscience

The Annesley EyeBrain Center

Exploring the links between the eyes and the brain, the work and research done at the Annesley EyeBrain Center is truly groundbreaking in the fields of neuroscience and ophthalmology. 

The William H. Annesley, Jr., MD ‘48 EyeBrain Center of the Vickie and Jack Farber Institute for Neuroscience at Thomas Jefferson University, in partnership with Wills Eye Hospital, is a centralized reading center. We specialize in providing leadership in research protocol development, training technicians and testing in both clinical and research applications.

Located in Claymont, Delaware the Annesley EyeBrain Center was established in 2005 as the Optic Nerve Research Center to serve the needs of the research community related to the eye. In June 2018, Thomas Jefferson University acquired certain assets of Optic Nerve Research Center, which is currently performing services as the Annesley EyeBrain Center.


The Annesley EyeBrain Center provides a variety of services, including:


  • Assistance with Protocol Development. Our board certified ophthalmologists will provide guidance for development of inclusion and exclusion criteria related to ophthalmic conditions for the study. We will recommend the best testing modalities to insure capturing data necessary to satisfy regulatory agencies about potential concerns about eye toxicity.
  • Recommendation to the Sponsor of the appropriate measurement tools.
  • Assistance/review of protocol sections and other study documents referring to ophthalmological exam.
  • Providing assistance, advice and feedback to participating sites in regard to ophthalmic results.
  • Attending periodic teleconferences with Sponsor/CRO, as required.
  • Assistance with justification of proposed measures with Ethics Committees, sites regulators and response to questions, etc.
  • Providing assistance, advice and feedback to Sponsor/CRO team in regard to implementation/interpretation and analysis of ophthalmological exams and outcomes.


  • Development of a Procedures Manual for Ophthalmic examination and testing, including detailed imaging instructions.
  • Creation of source documents and clinical research forms for use during the study.
  • Communication with the Sponsor/CRO, sites.
  • Secure electronic transfer of data from the sites.
  • Set-up, establishment and management of a secure database for tracking, data collection and data transfer to Sponsor/CRO.
  • Archiving of data and storage of electronic images with transfer of images to sponsor at study completion. 

Quality Review

  • Review of all materials received from the site for compliance with protocol requirements.
  • Review by technical staff for image quality. Implementation of repeat imaging procedures for poor quality images to insure reliability and reproducibility of data.


  • Training for sites in the various testing modalities; specifically Ocular Coherence Tomography (OCT) on all machine types including Heidelberg Spectralis and Carl Zeiss Meditec Cirrus machines.
  • Training will be provided through webcasts, as needed.

Reading Services 

  • Creation of Reader’s Manual, in accordance with study specific protocol to account for exclusion criteria and disease(s) being studied and standards for change evaluation.
  • Review of all ophthalmic test results for abnormalities prior to enrollment to insure compliance with exclusion criteria.
  • Review and comparison to baseline of all ophthalmic test results for change over time for potential drug related issues after enrollment by Board Certified Ophthalmologists.

Contact Us

1304 Society Drive
Claymont DE 19703

For more information regarding our services, please call: