Jefferson University Hospitals

Digestive Health Institute

Center for Genetic & Metabolic Liver Disease


The Center for Genetic and Metabolic Liver Disease – the first in the Delaware Valley – offers a multispeciality approach to the diagnosis and management of a rare group of disorders that can cause skin or neurologic problems.

Some people with genetic and metabolic liver diseases can develop a serious form of liver injury from an increased amount of scar tissue (fibrosis), which can lead to cirrhosis. Jefferson's experienced hepatologists screen for these complications and help manage patients with advanced fibrosis and end-stage liver disease.

Genetic & Metabolic Liver Disease Types

Jefferson's Center for Genetic and Metabolic Liver Disease experts offer specialized assessments and evaluations to treat the following rare disorders:

  • Hemochromatosis/Iron overload disorders, causing the body to absorb too much iron from the food you eat.
  • Wilson's disease, which causes copper to accumulate in your liver, brain and other organs.
  • Alpha-1 Antityrpsin Deficiency is a hereditary genetic disorder that can lead to lung and/or liver disease.

Why Choose Jefferson?

At our center, you have access to expert assessments into your medical history and risk factors for liver disease. Our multidisciplinary specialists use leading edge, minimally invasive technologies. These liver disease diagnostic tools and treatments include fibroscan and MR elastography to determine the extent of the liver damage.

Your care team consists of hepatologists (liver disease specialists), dietitians, pathologists and radiologists. We will set up an individualized treatment plan for you, which might include exclusive clinical trials (for those that meet criteria), and our leading Liver Transplant Program.

Our liver transplant surgeons have collectively performed more than 1,500 liver transplants at Jefferson and elsewhere, with some of the highest patient survival rates in the region. Our Liver Transplant Program achieved five out of five rating by the Scientific Registry of Transplant Recipients for one-year liver patient survival transplantation outcomes, which is among the top 10 percent in the nation.

Make An Appointment

Center City Philadelphia

132 South 10th Street, Suite 480
Philadelphia, PA 19107
Learn more about this location

Call 1-800-JEFF-NOW (1-800-533-3669) and ask to make an appointment with a specialist at the Center for Genetic and Metabolic Liver Disease, or make an appointment online.