Jefferson Health

Physician Profile

Michael Sperling, MD

Jefferson University Physician

Academic Title: Professor
Director, Jefferson Comprehensive Epilepsy Center
Director, Clinical Neurophysiology Laboratory

Neurology - Epilepsy

Make An Appointment

Click to call 1-800-JEFF-NOW (800-533-3669) or

Office Locations

909 Walnut Street
2nd Floor, COB Bldg.
Philadelphia PA 19107
Phone: (215) 955-1222
Fax: (215) 955-0606

Medical Services

Years in Practice


Board Certifications

  • Neurology
  • Clinical Neurophysiology

Hospital Affiliation / Admitting Privileges

  • Thomas Jefferson University Hospital

Awards and Honors

Philadelphia Magazine's Top Docs 2016,2015,2014,2013,2012,2011,2010


  • Temple University School of Medicine, Medical School


  • Mount Sinai Medical Center


  • Mount Sinai Medical Center, NY


  • UCLA Medical Center

Recent Publications

From “rest” to language task: Task activation selects and prunes from broader resting-state network

Contextually Mediated Spontaneous Retrieval Is Specific to the Hippocampus

Randomized, double-blind, placebo-controlled phase 2 study of ganaxolone as add-on therapy in adults with uncontrolled partial-onset seizures

Absolute spike frequency as a predictor of surgical outcome in temporal lobe epilepsy

Instruction manual for the ILAE 2017 operational classification of seizure types

Laser thermal ablation for treatment of drug-resistant epilepsy: Experiences from Philadelphia | Laser-Thermoablation zur Behandlung von pharmakoresistenten Epilepsien: Erfahrungen aus Philadelphia

Postsurgical outcome in patients with olfactory auras and drug-resistant epilepsy

Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study

Interictal epileptiform discharges impair word recall in multiple brain areas

Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy for Treatment of Drug-Resistant Epilepsy

Mesial temporal lobe epilepsy with childhood febrile seizure

Postsurgical outcome in patients with auditory auras and drug-resistant epilepsy

The Temporal Instability of Resting State Network Connectivity in Intractable Epilepsy

Longitudinal qualitative characterization of mri features after laser interstitial thermal therapy in drug-resistant epilepsy

Direct Electrical Stimulation of the Human Entorhinal Region and Hippocampus Impairs Memory

Clinical features and postoperative seizure outcome in patients with drug-resistant gelastic seizures without hypothalamic hamartoma

Ictal verbal help-seeking: Occurrence and the underlying etiology

Efficacy, safety, and tolerability of adjunctive brivaracetam for secondarily generalized tonic-clonic seizures: Pooled results from three Phase III studies

Remote preoperative tonic-clonic seizures do not influence outcome after surgery for temporal lobe epilepsy

Post–epilepsy surgery psychogenic nonepileptic seizures