Jefferson University Hospitals

Physician Profile

Michael Sperling, MD

Jefferson University Physician

Academic Title: Professor
Director, Jefferson Comprehensive Epilepsy Center
Director, Clinical Neurophysiology Laboratory

Neurology - Epilepsy

Make An Appointment

Click to call 1-800-JEFF-NOW (800-533-3669) or

Office Locations

909 Walnut Street
2nd Floor, COB Bldg.
Philadelphia PA 19107
Phone: (215) 955-1222
Fax: (215) 955-0606

Medical Services

Years in Practice


Board Certifications

  • Neurology
  • Clinical Neurophysiology

Hospital Affiliation / Admitting Privileges

  • Thomas Jefferson University Hospital

Awards and Honors

Philadelphia Magazine's Top Docs 2016,2015,2014,2013,2012,2011,2010


  • Temple University School of Medicine, Medical School


  • Mount Sinai Medical Center


  • Mount Sinai Medical Center, NY


  • UCLA Medical Center

Recent Publications

A method for the topographical identification and quantification of high frequency oscillations in intracranial electroencephalography recordings

Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively

Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition

Erratum to “Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study” (Epilepsy Res. (2017) 131 (70–75) (S0920121116302789) (10.1016/j.eplepsyres.2017.02.007))

Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy

Detection of generalized tonic–clonic seizures using surface electromyographic monitoring

Atlas of Electroencephalography, 3rd Edition

Similar patterns of neural activity predict memory function during encoding and retrieval

An interview with Sarah Weckhuysen, 2017 Epilepsia Prize Winner for Clinical Research

An interview with Tiwalade Sobayo, 2017 Epilepsia Prize Winner for Basic Science Research

Response to the numbering of seizure types

Presurgical thalamic "hubness" predicts surgical outcome in temporal lobe epilepsy

Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans

Laser thermal ablation for treatment of drug-resistant epilepsy: Experiences from Philadelphia | Laser-Thermoablation zur Behandlung von pharmakoresistenten Epilepsien: Erfahrungen aus Philadelphia

From “rest” to language task: Task activation selects and prunes from broader resting-state network

Stimulation of the human medial temporal lobe between learning and recall selectively enhances forgetting

Dissecting gamma frequency activity during human memory processing

Contextually Mediated Spontaneous Retrieval Is Specific to the Hippocampus

Randomized, double-blind, placebo-controlled phase 2 study of ganaxolone as add-on therapy in adults with uncontrolled partial-onset seizures

Absolute spike frequency as a predictor of surgical outcome in temporal lobe epilepsy