Jefferson University Hospitals

Physician Profile

Michael Sperling, MD

Jefferson University Physician

Academic Title: Professor
Director, Jefferson Comprehensive Epilepsy Center
Director, Clinical Neurophysiology Laboratory

Neurology - Epilepsy

Make An Appointment

Click to call 1-800-JEFF-NOW (800-533-3669) or

Office Locations

909 Walnut Street
2nd Floor, COB Bldg.
Philadelphia PA 19107
Phone: (215) 955-1222
Fax: (215) 955-0606

Medical Services

Years in Practice


Board Certifications

  • Neurology
  • Clinical Neurophysiology

Hospital Affiliation / Admitting Privileges

  • Thomas Jefferson University Hospital

Awards and Honors

Philadelphia Magazine's Top Docs 2016,2015,2014,2013,2012,2011,2010


  • Temple University School of Medicine, Medical School


  • Mount Sinai Medical Center


  • Mount Sinai Medical Center, NY


  • UCLA Medical Center

Recent Publications

Similar patterns of neural activity predict memory function during encoding and retrieval

Response to the numbering of seizure types

Presurgical thalamic "hubness" predicts surgical outcome in temporal lobe epilepsy

Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans

Laser thermal ablation for treatment of drug-resistant epilepsy: Experiences from Philadelphia | Laser-Thermoablation zur Behandlung von pharmakoresistenten Epilepsien: Erfahrungen aus Philadelphia

From “rest” to language task: Task activation selects and prunes from broader resting-state network

Stimulation of the human medial temporal lobe between learning and recall selectively enhances forgetting

Dissecting gamma frequency activity during human memory processing

Contextually Mediated Spontaneous Retrieval Is Specific to the Hippocampus

Randomized, double-blind, placebo-controlled phase 2 study of ganaxolone as add-on therapy in adults with uncontrolled partial-onset seizures

Absolute spike frequency as a predictor of surgical outcome in temporal lobe epilepsy

Instruction manual for the ILAE 2017 operational classification of seizure types

Drug-resistant parietal lobe epilepsy: clinical manifestations and surgery outcome

Postsurgical outcome in patients with olfactory auras and drug-resistant epilepsy

Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study

Interictal epileptiform discharges impair word recall in multiple brain areas

New definition and classifications of epilepsy among highlights of the American epilepsy society annual meeting

Epileptologist's view: Laser interstitial thermal ablation for treatment of temporal lobe epilepsy

Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy for Treatment of Drug-Resistant Epilepsy

Mesial temporal lobe epilepsy with childhood febrile seizure