Jefferson University Hospitals

Physician Profile

Stephen Silberstein, MD

Jefferson University Physician

Academic Title: Professor
Director, Headache Center

Neurology - Headaches

Make An Appointment

Click to call 1-800-JEFF-NOW (800-533-3669) or

Office Locations

900 Walnut Street
2nd Floor, Ste. 200
Philadelphia PA 19107
Phone: (215) 955-2243
Fax: (215) 955-2763

Medical Services

Years in Practice


Board Certifications

  • Neurology

Hospital Affiliation / Admitting Privileges

  • Thomas Jefferson University Hospital
  • Methodist Hospital Division of Thomas Jefferson University Hospital

Awards and Honors

Philadelphia Magazine's Top Docs 2016,2015,2014,2013,2012,2011,2010


Practice limited to treatment of headaches


  • University of Pennsylvania School of Medicine, Medical School


  • Hospital of the University of Pennsylvania


  • Hospital of the University of Pennsylvania


  • National Institute of Health



Recent Publications

Erenumab (AMG 334) in episodic migraine: Interim analysis of an ongoing open-label study

AVP-825: a novel intranasal delivery system for low-dose sumatriptan powder in the treatment of acute migraine

Early Onset of Efficacy and Consistency of Response Across Multiple Migraine Attacks From the Randomized COMPASS Study: AVP-825 Breath Powered® Exhalation Delivery System (Sumatriptan Nasal Powder) vs Oral Sumatriptan

Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial

Insights into the Functional Anatomy Behind the PREEMPT Injection Paradigm: Guidance on Achieving Optimal Outcomes

Vagus Nerve Stimulation and Headache

Interneuronal transfer and distal action of tetanus toxin and botulinum neurotoxins a and D in central neurons

Topiramate in Migraine Prevention: A 2016 Perspective

Histamine and Migraine


Inhaled drug therapy development for the treatment of migraine

Chronic migraine headache prevention with noninvasive vagus nerve stimulation: The EVENT study

The migraine postdrome

Considerations for management of migraine symptoms in the primary care setting

The American Headache Society Cluster Guidelines

How to Apply the AHS Evidence Assessment of the Acute Treatment of Migraine in Adults to your Patient with Migraine

Long-Term Pain Reduction Does Not Imply Improved Functional Outcome in Patients Treated With Combined Supraorbital and Occipital Nerve Stimulation for Chronic Migraine

The Management of Adults with Acute Migraine in the Emergency Department

Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect | Neurotoxina botulínica do tipo-A quando utilizada em animais com sensibilização trigeminal induz efeito antinociceptivo

Erratum to: Targeting CGRP: A New Era for Migraine Treatment (CNS Drugs, (2015), 29, 443-452, DOI:10.1007/s40263-015-0253-z)