Jefferson University Hospitals

Provider Profile

Stephen Silberstein, MD

Jefferson University Physician

Academic Title: Professor
Director, Headache Center

Neurology - Headaches

Make An Appointment

Click to call 1-800-JEFF-NOW (800-533-3669) or

Office Locations

900 Walnut Street
2nd Floor, Ste. 200
Philadelphia PA 19107
Phone: (215) 955-2243
Fax: (215) 955-2060

Medical Services

Years in Practice


Board Certifications

  • Neurology

Hospital Affiliation / Admitting Privileges

  • Thomas Jefferson University Hospital
  • Methodist Hospital Division of Thomas Jefferson University Hospital

Awards and Honors

Philadelphia Magazine's Top Docs 2016,2015,2014,2013,2012,2011,2010


Practice limited to treatment of headaches


  • University of Pennsylvania School of Medicine, Medical School


  • Hospital of the University of Pennsylvania


  • Hospital of the University of Pennsylvania


  • National Institute of Health



Recent Publications

AVP-825 (Sumatriptan Nasal Powder) Reduces Nausea Compared to Sumatriptan Tablets: Results of the COMPASS Randomized Clinical Trial

A review of clinical safety data for sumatriptan nasal powder administered by a breath powered exhalation delivery system in the acute treatment of migraine

Histamine and Migraine

Percutaneous Closure of Patent Foramen Ovale in Patients With Migraine: The PREMIUM Trial

Current management: Migraine headache

CGRP Monoclonal Antibodies for Migraine: Rationale and Progress

Fremanezumab for the preventive treatment of chronic migraine

Neuroemergency Clinical Trials: Migraine

Erenumab (AMG 334) in episodic migraine

AVP-825: a novel intranasal delivery system for low-dose sumatriptan powder in the treatment of acute migraine

Early Onset of Efficacy and Consistency of Response Across Multiple Migraine Attacks From the Randomized COMPASS Study: AVP-825 Breath Powered® Exhalation Delivery System (Sumatriptan Nasal Powder) vs Oral Sumatriptan

Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial


Insights into the Functional Anatomy Behind the PREEMPT Injection Paradigm: Guidance on Achieving Optimal Outcomes

Vagus Nerve Stimulation and Headache

Topiramate in Migraine Prevention: A 2016 Perspective

Interneuronal transfer and distal action of tetanus toxin and botulinum neurotoxins a and D in central neurons

AVP-825 (Sumatriptan Nasal Powder) Reduces Nausea Compared to Sumatriptan Tablets: Results of the COMPASS Randomized Clinical Trial


Inhaled drug therapy development for the treatment of migraine