Jefferson University Hospitals

Physician Profile

Steven McKenzie, MD

Jefferson University Physician

Academic Title: Professor
Director, Division of Hematology

Specialties
Hematology (Not Accepting New Patients)
Pediatrics - Hematology/Oncology

Make An Appointment

Click to call 1-800-JEFF-NOW (800-533-3669) or

Office Locations

Philadelphia
1015 Chestnut Street
Suite 1020
Philadelphia PA 19107
Phone: (215) 955-4730
Fax: (215) 503-9188

Medical Services

Years in Practice

26

Board Certifications

  • Pediatric Hematology-Oncology
  • Pediatrics

Hospital Affiliation / Admitting Privileges

  • Thomas Jefferson University Hospital

Education

  • University of Pennsylvania School of Medicine, Medical School

Internship

  • Children's Hospital of Philadelphia

Residency

  • Children's Hospital of Philadelphia

Fellowship

  • Children's Hospital of Philadelphia

Recent Publications

5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies

Erratum: TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346, a regulatory site of Syk (The Journal of Biological Chemistry (2016) 291 (22427-22441) DOI: 10.1074/jbc.M116.743732)

Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia

TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice

TULA-2 protein phosphatase suppresses activation of syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346a regulatory site of syk

The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)

Syk inhibition in ischemic stroke

Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs

Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation

MicroRNA expression differences in human hematopoietic cell lineages enable regulated transgene expression

Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics

The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome

Identification of a developmental gene expression signature, including hox genes, for the normal human colonic crypt stem cell niche: Overexpression of the signature parallels stem cell overpopulation during colon tumorigenesis

Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia

CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes

Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms

MicroRNAs in platelet production and activation

Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo

The complex transcriptional landscape of the anucleate human platelet