Jefferson University Hospitals

Physician Profile

Karen Gripp, MD

Academic Title: Professor

Pediatrics - Medical Genetics

Make An Appointment

Click to call 1-800-JEFF-NOW (800-533-3669) or

Office Locations

duPont Hospital for Children
1600 Rockland Road
Wilmington DE 19803
Phone: (302) 651-5916

Medical Services

Board Certifications

  • Pediatrics
  • Clinical Genetics
  • Clinical Molecular Genetics

Hospital Affiliation / Admitting Privileges

  • Thomas Jefferson University Hospital

Awards and Honors

Philadelphia Magazine's Top Docs 2016


  • University of Hamburg, Medical School


  • Thomas Jefferson University Hospital


  • Thomas Jefferson University Hospital


  • Children's Hospital of Philadelphia


Recent Publications

Expanding the neurodevelopmental phenotype of PURA syndrome

X-linked hypomyelination with spondylometaphyseal dysplasia (H-SMD) associated with mutations in AIFM1

Constitutional LZTR1 mutation presenting with a unilateral vestibular schwannoma in a teenager

Attenuated phenotype of Costello syndrome and early death in a patient with an HRAS mutation (c.179G>T; p.Gly60Val) affecting signalling dynamics

Phenotypic and molecular characterisation of CDK13-related congenital heart defects, dysmorphic facial features and intellectual developmental disorders

Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements

Age-related differences in prevalence of autism spectrum disorder symptoms in children and adolescents with Costello syndrome

Phenotypic spectrum of Costello syndrome individuals harboring the rare HRAS mutation p.Gly13Asp

Cytotoxicity of zardaverine in embryonal rhabdomyosarcoma from a Costello syndrome patient

A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affecting codon 146—Literature review and update

Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly

The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

Paternal uniparental disomy with segmental loss of heterozygosity of chromosome 11 are hallmark characteristics of syndromic and sporadic embryonal rhabdomyosarcoma

Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation

A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair

The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway

The role of objective facial analysis using FDNA in making diagnoses following whole exome analysis. Report of two patients with mutations in the BAF complex genes

36th Annual David W. Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2015 annual meeting

Maternal uniparental disomy of chromosome 20: A novel imprinting disorder of growth failure

Paternal uniparental disomy 11p15.5 in the pancreatic nodule of an infant with Costello syndrome: Shared mechanism for hyperinsulinemic hypoglycemia in neonates with Costello and Beckwith-Wiedemann syndrome and somatic loss of heterozygosity in Costello syndrome driving clonal expansion