Jefferson Health

Cowden Syndrome

Cowden syndrome is a rare autosomal dominant disorder that can increase your risk of breast cancer. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN and is a genetic syndrome. If you know that someone in your family had cowden syndrome or are concerned that you might have this condition, consult the experts of Jefferson's Hereditary Cancer Program, who are dedicated to identifying and managing individuals with a known or suspected inherited predisposition to cancer.

A multidisciplinary team of genetic counselors, oncology nurses, surgeons, molecular geneticists, a clinical geneticist and others staff the Program. We will evaluate your family history and develop a written risk assessment and a cancer screening program for you and your at-risk family members. Your evaluation will also be given to your referring physician.

The Program takes a multidisciplinary approach to cancer risk evaluation and is one of few programs to offer cancer risk counseling for any type of cancer, including pediatric cancers.