Jefferson University Hospitals

Basal Cell Nevus Syndrome (Gorlin Syndrome)

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The risk for ovarian cancer and skin cancer is increased with basal cell nevus syndrome (also called Gorlin syndrome and nevoid basal cell carcinoma syndrome), a rare autosomal dominant cancer genetic syndrome.

If you are diagnosed with ovarian cancer, specialists in Jefferson's Division of Gynecologic Oncology have expertise in treating women with both premalignant and malignant conditions of the reproductive organs. Our physicians also provide care for women at higher-than-usual risk for gynecologic cancer based upon a personal history or genetic predisposition.

Specialists in the Division are members of the Kimmel Cancer Center at Jefferson and often collaborate with other Jefferson cancer specialists, especially radiotherapists. The Division participates as Principal Investigators with the Gynecologic Oncology Group (GOG), the national cooperative research organization for investigating new therapeutic approaches.

If you are diagnosed with skin cancer, specialists in Jefferson's Division of Cutaneous Surgery offers skin cancer screening exams, consultative evaluations, and treatment of all types of symptomatic benign growths, pigmented lesions, and skin cancers. Our specially trained faculty utilize advanced conventional, Mohs and laser surgical techniques to provide patients with the most flexible options for effective treatment of a wide range of skin conditions and for removal of skin lesions. In addition to patient care, the Department’s world class research programs facilitate clinical studies, investigate advances in dermatologic therapies and engage in studies of genetic skin diseases, connective-tissue disorders and skin cancers.

Genetic Predisposition

If you want to determine your genetic predisposition to ovarian cancer or skin cancer, consult the experts in Jefferson's Hereditary Cancer Program, who are dedicated to identifying and managing individuals with a known or suspected inherited predisposition to cancer.

A multidisciplinary team of genetic counselors, oncology nurses, surgeons, molecular geneticists, a clinical geneticist and others will evaluate your family history and develop a written risk assessment and a cancer screening program for you and your at-risk family members. Your evaluation will also be given to your referring physician.

The Program takes a multidisciplinary approach to cancer risk evaluation and is one of the few to offer cancer risk counseling for any type of cancer, including pediatric cancers.